Current Literature in Glycobiology / Glyco Journal Club

MED 246 / CMM 246 | Fall, Winter, Spring Quarters | Fridays 12:00–1:00 p.m. (pacific time)
Location: In person, Biomedical Research Facility 2, Room 4103
Course Director: Philip Gordts
Co-Instructors: Jeffrey D. Esko, Pascal Gagneux, Ajit Varki, Kamil Godula, Amanda Lewis, Lars Bode
Course TA: Chelsea Painter
Units: 1

Spring 2023 First day & Orientation: Friday, April 14, 2023

Symbol Nomenclature for Glycans (SNFG):
https://www.ncbi.nlm.nih.gov/glycans/snfg.html

Harrison's Principles of Internal Medicine:
https://accessmedicine.mhmedical.com/book.aspx?bookid=3095

Current Literature in Glycobiology is a one-credit (per quarter) elective that provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants and microbes, as well as medical aspects of glycobiology.

DATE	PAPER TITLE	PRESENTER
9/23/22	Course Introduction / Paper Selection Essentials of Glycobiology 4th Associated Resources (PDF)	Professor, Philip Gordts Postdoc, Chelsea Painter
9/30/22	NO CLASS
10/7/22	Origin of cytoplasmic GDP-fucose determines its contribution to glycosylation reactions (PDF)	Chelsea Painter (Gordts Lab)
10/14/22	Establishment of fetomaternal tolerance through glycan-mediated B cell suppression (PDF)	Jill Hauer (Esko Lab)
10/21/22	Revealing the human mucinome (PDF)	Sridevi Krishnan (N. Lewis Lab)
10/28/22	Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate (PDF)	Julianna Follmar (Godula Lab)
11/4/22	Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo (PDF)	Francesca Boscolo (Alperin Lab)
11/11/22	NO CLASS - VETERANS HOLIDAY
11/18/22	NO CLASS
11/25/22	NO CLASS - THANKSGIVING HOLIDAY
12/2/22	N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease (PDF)	Juston Jaco (A. Varki Lab)
12/9/22	Glycan degradation promotes macroautophagy (PDF)	Stephanie Leal (Gordts Lab)
12/16/22	NO CLASS - CHRISTMAS HOLIDAY
12/23/22	NO CLASS - CHRISTMAS HOLIDAY
12/30/22	NO CLASS - NEW YEARS HOLIDAY
1/6/23	NO CLASS
1/13/23	Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation (PDF)	Graham Heberlig (Burkart Lab)
1/20/23	Course Introduction / Paper Selection	Professor, Philip Gordts Postdoc, Chelsea Painter
1/27/23	Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions (PDF)	Jaclyn Swan (Gagneux Lab)
2/3/23	Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment (PDF)	Sydney Morrill (A. Lewis Lab)
2/10/23	Noninvasive detection of any-stage cancer using free glycosaminoglycans (PDF)	Marissa Maciej-Hulme (Gordts Lab)
2/17/23	Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1 (PDF)	Reid Larson (Daneman Lab)
2/24/23	ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface (PDF)	Hyemin Song
3/3/23	N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase (PDF)	Linda Li
3/10/23	A mutated glycosaminoglycan-binding domain functions as a novel probe to selectively target heparin-like epitopes (PDF)	Nathan Thomas (Gordts Lab)
3/17/23	A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis (PDF)	Natasha Carlson
3/24/23	Cell-specific bioorthogonal tagging of glycoproteins (PDF)	Jason Hsaio (Gordts Lab)
3/31/23	NO CLASS - CESAR CHAVEZ HOLIDAY
4/7/23	NO CLASS - SAN DIEGO GLYCOBIOLOGY SYMPOSIUM
4/14/23	Course Introduction / Paper Selection	Professor, Philip Gordts Postdoc, Chelsea Painter
4/21/23	NO CLASS
4/28/23	Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism (PDF)	Tricia Lenhart-Pendergrass (Nizet Lab)
5/5/23	Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins (PDF)	Jessica Pihl (Esko Lab)
5/12/23
5/19/23	Gaucher disease protects against tuberculosis (PDF)	Sudeshna Saha (A. Lewis lab)
5/26/23	Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis (PDF)	Jessica Perez-Ochoa (Esko Lab)
6/2/23	Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation (PDF)	Staci Barnes (Godula Lab)
6/9/23	Steric pressure between glycosylated transmembrane proteins inhibits internalization by endocytosis (PDF)	PK Choudhary (Godula Lab)

Contact

If you are off campus and would like access to course materials, contact Tracy:

Tracy Gilstrap
Education Program Specialist
(858) 882-1378
tgilstrap@health.ucsd.edu