Current literature in glycobiology 2011/2012

(MED 246 | BIOM 246 | CMM 246)
FA11, WI12, SP12
Fridays from 12:00pm - 1:00pm
CMM-East, Room 1079 (1st Floor Conference Room)

Previous Years: 2010-2011, 2009-2010.

Publications are presented in an informal discussion setting to students, post-docs and faculty. Typcially, there are 20-25 weekly attendees. Links to PubMed for each article is provided below. Topics include glycan chemistry, biochemistry, genetics, cell biology and molecular biology in animals, plants and microbes as well as medical aspects of glycobiology. Registration for the course (1 credit per quarter) is done through the registrar's office.

Faculty Instructors: Drs. Lars Bode, Jeffrey Esko, Pascal Gagneux & Ajit Varki

Friday Publication Presented By Full Text
Sept 16 Course Welcome
Lars Bode, Assistant Professor
Guidelines & Intro Image of a pdf symbol
Sept 23 Marschner K. et al (2011) A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Science 333(6038):87-90. PMID2171967
Ajit Varki, Distinguished Professor
Article
Supplemental Image of a pdf symbol
Sept 30 Settembre C. et al (2011) TFEB Links Autophagy to Lysosomal Biogenesis. Science 332(6036):1429-33. PMID21617040
Chris Lamanna, Postdoctoral Fellow
Article Image of a pdf symbol
Oct 7 Carette JE. et al (2011) Ebola virus entry requires the cholestrol transporter Niemann-Pick C1. Nature 477(7364):340-3. PMC3175325
Philip Gordts, Postdoctoral Fellow
Article
Supplemental Image of a pdf symbol
Oct 14 Russell AB. et al (2011) Type VI secretion delivers bacteriolytic effectors to target cells. Nature 475(7356):343-7. PMC3146020.
Evelyn Jantscher-Krenn,
Postdoctoral Fellow
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Oct 21 Kashyap DR et al (2011) Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nat Med 17(6):676-83. PMC3176504.
Bryan Thacker, Predoctoral Scholar
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Oct 28 Chad T et al (2011) An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nature Biotech 29, 829-834. PMID21841799.
Anne Bergfeld, Postdoctoral Fellow
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Nov 4
Cancelled
Roger Lawrence, Asst. Proj Sci
Nov 18 Xu Y. et al (2011) Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins. Science 334 (6055): 498-501. PMID 22034431
Roger Lawrence, Asst. Proj Sci
Article Image of a pdf symbol
Dec 2 Ohtsubo K. et al (2011) Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med 17 (9): 1067-75. dpi: 10.1038/nm.2414. PMID 21841783
Jon Gonzales, Predoctoral Fellow
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Dec 9 Vaishnava S. et al (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334(6053):255-8. PMID 21998396
Leela Davies, MSTP
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Jan 6 Lam, KK et al (2011) Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. J Biol Chem 286(43): 37118-27. PMC3199459
Nissi Varki, Professor
Article Image of a pdf symbol
Jan 13 Brennan, P et al (2011) Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol 12 (12):1202-11. PMC3242449
Raza Ali, Postdoctoral Fellow
Article Image of a pdf symbol
Jan 20 Commins, SP et al (2011) The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol 127 (5):1286-93. PMC30856434
Pascal Gagneux, Assistant Professor
Article Image of a pdf symbol
Jan 27 Pejchal, R et al (2011) A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield. Science 334 (6059), 1097-103. PMID 21998254
Vered Karavani, Asst Proj Sci
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Feb 3 Pang, PC et al (2011) Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science 333 (6050):1761-4. PMID 21852454
Chloe Autran, Postdoctoral Fellow
Article Image of a pdf symbol
Feb 10 Avci, FY et al (2011) A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design. Nat Med 17 (12):1602-9. PMID 22101769
Jun Muto, Postdoctoral Fellow
Article Image of a pdf symbol
Feb 17 Thurston, T. et al (2012) Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature doi: 10.1038/nature10744. [Epub ahead of print] PMID 22246324
Emylie Seamen, Postdoctoral Fellow
Article Image of a pdf symbol
Feb 24 Kalinina J. et al (2012) The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition. Structure 20 (1):77-88. PMID 22244757
Jeffrey Young, Masters Student
Article Image of a pdf symbol
Supplemental Image of a pdf symbol
Mar 2 Lewis, WG et al (2011) Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. J Biol Chem 287 (3):2079-89. PMC3265887
Markus Roupé, Postdoctoral Fellow
Article Image of a pdf symbol
Mar 9 Surviladze, Z et al (2012) Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections. PLoS Pathog (2) e1002519. PMC3276557
Nina Schommer, Postdoctoral Fellow
Article Image of a pdf symbol
Mar 23
Cancelled
Fang Ma, Postdoctoral Fellow

Apr 6 Inamori, K et al (2012) Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science 335(6064):93-6. PMID 22223806
Flavio Schwarz, Postdoctoral Fellow
Article Image of a pdf symbol
Supplement Image of a pdf symbol
Apr 13 Ramani, VC et al (2012) Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding*. J Biol Chem 287(13):9952-61. PMID 22298773
Erin Foley, Predoctoral Scholar
Article Image of a pdf symbol
Apr 20 Børud, B et al (2011) Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system. Proc Natl Acad Sci USA 108(23):9643-8. PMC3111294
Xiaoxia Wang, Postdoctoral Fellow
Article Image of a pdf symbol
Apr 27 Hu L, et al (2012) Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature doi:10.1038/nature10996 [Epub ahead of print] PMID 22504179
Lingquan Deng, Postdoctoral Fellow
Article Image of a pdf symbol
Supplement Image of a pdf symbol
May 4 Thompson, A. J. et al (2012) Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase. PNAS 109 (3): 781-786. PMC3271872
Oliver Pearce, Postdoctoral Fellow
Article Image of a pdf symbol
May 11 Rexach JE et al (2012) Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nat Chem Biol 8(3):253-61. PMID: 22267118
Miriam Cohen, Asst Proj Sci
Article Image of a pdf symbol
May 18 Kolodkin-Gal I, et al (2012) A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide. Cell 49(3):684-92. PMID 22541437
Wenyong Tong, Postdoctoral Fellow
Article Image of a pdf symbol
May 25 Takagi H et al. (2011) Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity 35: 958-71. PMID 22177923
Masaya Yamaguchi, Visiting Scholar
Article Image of a pdf symbol
Supplement Image of a pdf symbol
Jun 1 Yu SH et al. (2012) Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc Natil Acad Sci U.S.A. 109:4834-9. PMC3323966
Xander van Wijk, Postdoctoral Fellow
Article Image of a pdf symbol
Jun 8 Provenzano, PP et al, (2012) Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21:418-29. PMID 22439937
Heinz Laubli, Postdoctoral Fellow
Article Image of a pdf symbol
Jun 15 Battula VL et al (2012) Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest pii: 59735. doi: 10.1172/JCI59735 PMID 22585577
Spencer Wei, Predoctoral Scholar
Article Image of a pdf symbol
top