| Date |
Topic (s) |
Chapter # |
Instructor(s) |
T = Tuesday
H = Thursday |
General Principles
|
|
|
| Mar 30 (T) |
Historical background & Course Overview. General terms
&definitions.
Cellular Organization of Glycosylation   |
1 |
Varki |
| |
Biological roles of Glycans /
Evolutionary considerations
in understanding Glycan Diversity
|
3,5 |
Varki |
| Apr 1 (H) |
Saccharide Structure & Nomenclature
|
2 |
Finney |
| |
Glycosylation Precursors
(Cellular metabolism of monosaccharide precursors and sugar nucleotides)
|
6 |
Freeze |
| |
Structure, Biosynthesis and Turnover
|
|
|
| Apr 6 (T) |
N Glycans
|
7 |
Varki |
| |
O Glycans
|
8 |
Esko |
| Apr 8 (H) |
Glycosphingolipids
|
9 |
Varki |
| |
Glycophospholipid anchors
|
10 |
Freeze |
| Apr 13 (T) |
Sulfated Glycosaminoglycans and
Hyaluronan
|
11 |
Esko |
| |
Sialic Acids
|
15 |
Varki |
| Apr 15 (H) |
Glycosyltransferases:
Biochemistry, Cell Biology, Genetics
|
17 |
Paulson |
| |
Outer structures common to
different types of glycans
|
16 |
Paulson |
| Apr 20 (T) |
Other types of Golgi-mediated
glycosylation
|
12 |
Freeze |
| |
Lysosomal degradation of
glycoconjugates (including inherited Genetic Disorders)
|
18 |
Freeze |
| Apr 22 (H) |
The O-GlcNAc Modification
|
14 |
Freeze |
| |
Other types of Nuclear &
Cytoplasmic glycosylation
|
13 |
Freeze |
| |
Protein-Glycan Interactions
|
|
|
| Apr 27 (T) |
Discovery and Classification of Glycan-Recognizing Proteins
|
22 |
Varki |
| |
Principles of Glycan Recognition
|
4 |
Esko |
| Apr 29 (H) |
R- and L-Type Lectins. Glycoproteins in Quality Control and Secretion
|
7,30 |
Varki |
| |
The "P-Type" Lectins and the Trafficking of Lysosomal Enzymes
|
23 |
Varki |
| May 4 (T) |
The Galectins (Formerly "S-Type" Lectins)
|
27 |
Cummings |
| |
The "C-Type" Lectins and the Selectins
|
25,26 |
Cummings |
| May 6 (H) |
Glycans in Parasitic Infections
|
36 |
Cummings |
| |
Plant Lectins: Discovery, Characterization and Utility
|
30 |
Cummings |
| May11 (T) |
Glycosaminoglycan-Binding Proteins
|
29 |
Esko |
| |
Microbial Adhesins, Agglutinins and Toxins
|
28 |
Nizet |
| |
Organismal Diversity in Glycans
|
|
|
| May13 (H) |
Unicellular Organisms (Eubacteria, Archea and Yeast)
|
21 |
Esko |
| |
Multicellular Model Animals (Drosophila, C. elegans, Sea Urchins, Xenopus, Zebrafish, Mice)
|
19 |
Selleck |
| May18 (T) |
Plant Glycans
|
20 |
Etzler |
| |
Free Glycans and Their Role as Signaling Molecules
|
20 |
Etzler |
| |
Glycans in Normal Physiology and Disease
|
|
|
| May 20 (H) |
The "I-Type" Lectins and the Siglecs
|
24 |
Varki |
| |
Glycobiology of Fertilization and Reproduction
|
34 |
Vacquier |
| May 25 (T) |
Cultured Cell Lines with Genetically Defined Disorders of Glycosylation
|
31 |
Esko |
| |
Genetic Disorders of Glycosylation in Humans
|
32 |
Freeze |
| May 27 (H) |
Changes of Glycosylation in Cancer
|
35 |
Varki |
| |
Changes in Glycosylation in Other Systemic Diseases
|
37 |
Varki |
| |
Methods and Applications
|
|
|
| June 1 (T) |
Analysis and Sequencing of Glycans (Including Antibodies and Lectins)
|
2,38 |
Hayes |
| |
Glycomics and Bioinformatics
|
2,38 |
Paulson |
| June 3 (H) |
Chemical Synthesis of Glycans and Glycoconjugates
|
39 |
Van Nieuwenhze |
| |
Enzymatic Synthesis of Glycans and Glycoconjugates
|
39 |
Van Nieuwenhze |
| June 8 (T) |
Chemical Tools for Studying and Perturbing Glycans. Glycan Arrays
|
40 |
Bertozzi |
| |
Glycans in Biotechnology and Pharmaceutical Industry
|
41 |
Bertozzi |
| June 10 (H) |
Course Overview. Examination Papers
|
|
Varki |
