Essentials of Glycobiology
Spring 2008

The course materials below are made available primarily for the students and instructors. Others are welcome to look at them. However, if you wish to use the slides or modified versions of the same for any educational/academic purposes, please first obtain permission from the specific instructor(s) involved. Commercial uses of the course materials are strictly prohibited.

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Date Topic (s) Chapter # Instructor(s)
M = Monday
Th = Thursday
Essentials of Glycobiology
Mar 27 (Th) Course Overview. History of Glycobiology, Primer on Glycans Lectins, and Biological FunctionsLecture 1 slides 1,6,(2) Esko/Varki
Mar 31 (M) Cellular Organization and Transferase StructureLecture 2 slides 3,5 Paulson
Apr 3 (Th) Lectins and Principles of Glycan RecognitionLecture 3 slides 26 (27) Esko
Apr 7 (M) Assembly of precursorsLecture 4 Slides 4 Freeze
Apr 10 (Th) N-glycans and Quality ControlLecture 5 slides 8 (36) Freeze
Apr 14 (M) O-Glycans and C-type lectinsLecture 6 slides 9 (31) Esko
Apr 17 (Th) Glycosphingolipids and GPI anchorsLecture 7 slides 10,11 Esko
Apr 21 (M) Proteoglycans, hyaluronan and binding proteinsLecture 8 Slides (15) 16, 36 Esko
Apr 24 (Th) Glycans and signaling 37, 12 (notch) Gagneux
Apr 28 (M) Nuclear and cytoplasmic glycosylation, O-GlcNAcLecture 10 Slides (17) 18 Varki
May 1 (Th) Sialic acids and I-type lectinsLecture 11 Slides 14, 32 Varki
May 5 (M) GalectinsLecture 12 slides (13) 33 Varki
***May 9 (FRIDAY)***SCHEDULE CHANGE Lysosomal degradation and P-type lectinsSlides lecture 13 (41) 30 Freeze
May 12 (M) Plants and L-type lectins (22) 29, 45 Varki
May 15 (Th) R-type lectins 28 Varki
May 19 (M) Genomics & evolution 7, 19 Gagneux
May 22 (Th) Glycan Synthesis, and Glycomics (47) 48, 49 Guest Lecturer - Dr. Carolyn Bertozzi, UC Berkeley
May 29 (Th) Microbial Cell Walls and Colonization 20 (21,34) Esko
Jun 2 (M) Microbial infection 39 (40) Esko
Jun 5 (Th) Glycans in development 23 (24, 25, 38) Esko
Jun 9 (M) Genetic disorders and acquired diseases 42 (43, 44, 46) Freeze
Jun 12 (Th) Inhibitors and pharmaceutical design 50, 51 Esko